Samantha is an alternative universe counterpart of Sam Sinister who originates in the Earth-2 universe. In this universe she was murdered by a cult working for The Company.

She appears exactly like Sam Sinister. Her photograph was seen when Mr. Sinister does research on Nathan and finds an article on Samantha's murder, which is deemed to be a cold case by the authorities due to them not uncovering any information on the Company's involvement. Nathan was initially a suspect in her murder, but wasn't charged due to lack of evidence. Her death is what drives Nathan to take down the Company.